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Aurora B kinase phosphorylates and instigates degradation of p53
Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in many types of human cancers, which has made it an attractive target for cancer therapies. Tumor suppressor...
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| Главные авторы: | , , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3386093/ https://ncbi.nlm.nih.gov/pubmed/22611192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110287109 |
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