Aurora B kinase phosphorylates and instigates degradation of p53

Aurora B is a mitotic checkpoint kinase that plays a pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in many types of human cancers, which has made it an attractive target for cancer therapies. Tumor suppressor...

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Autores principales: Gully, Chris P., Velazquez-Torres, Guermarie, Shin, Ji-Hyun, Fuentes-Mattei, Enrique, Wang, Edward, Carlock, Colin, Chen, Jian, Rothenberg, Daniel, Adams, Henry P., Choi, Hyun Ho, Guma, Sergei, Phan, Liem, Chou, Ping-Chieh, Su, Chun-Hui, Zhang, Fanmao, Chen, Jiun-Sheng, Yang, Tsung-Ying, Yeung, Sai-Ching J., Lee, Mong-Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386093/
https://ncbi.nlm.nih.gov/pubmed/22611192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110287109
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