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COP 9 Signalosome Subunit 6 Stabilizes COP1, which Functions as an E3 Ubiquitin Ligase for 14-3-3σ
14-3-3σ, a gene upregulated by p53 in response to DNA damage, exists as part of a positive-feedback loop which activates p53 and is a human cancer epithelial marker downregulated in various cancer types. 14-3-3σ levels are critical for maintaining p53 activity in response to DNA damage and regulatin...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358116/ https://ncbi.nlm.nih.gov/pubmed/21625211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.192 |
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