14-3-3σ exerts tumor suppressor activity mediated by regulation of COP1 stability

COP1 is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that remain obscure. Here we report that COP1 is not downregulated following DNA damage in 14-3-3σ null cells, implicating 14-3-3σ as a critical regulator in the response of COP1 to DNA damage. We also...

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Detalhes bibliográficos
Main Authors: Su, Chun-Hui, Zhao, Ruiying, Zhang, Fanmao, Qu, Changju, Chen, Bo, Feng, Yin-Hsun, Phan, Liem, Chen, Jian, Wang, Hua, Wang, Huamin, Yeung, Sai-Ching J., Lee, Mong-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358120/
https://ncbi.nlm.nih.gov/pubmed/21135113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2518
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