HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53

HER2/neu oncogene is frequently overexpressed in various types of cancer, and the (PI3K)-Akt signaling pathway is often activated in HER2-overexpressing cancer cells. CSN6, subunit 6 of the COP9 signalosome complex, is pivotal in regulating MDM2 to destabilize p53, but its upstream regulators remain...

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Autori principali: Xue, Yuwen, Chen, Jian, Choi, Hyun-Ho, Phan, Liem, Chou, Ping-Chieh, Zhao, Ruiying, Yang, Huiling, Santiago, Janice, Liu, Mo, Yeung, Giselle E., Yeung, Sai-Ching J., Lee, Mong-Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524214/
https://ncbi.nlm.nih.gov/pubmed/23095642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22413
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