CDK inhibitor p57(Kip2) is negatively regulated by COP9 signalosome subunit 6

Subunit 6 of the COP9 signalosome complex, CSN6, is known to be critical to the regulation of the MDM2-p53 axis for cell proliferation and anti-apoptosis, but its many targets remain unclear. Here we show that p57(Kip2) is a target of CSN6, and that CSN6 is a negative regulator of p57(Kip2). CSN6 as...

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Hoofdauteurs: Chen, Bo, Zhao, Ruiying, Su, Chun-Hui, Linan, Monica, Tseng, Chieh, Phan, Liem, Fang, Lekuan, Yang, Heng-Yin, Yang, Huiling, Wang, Wenqian, Xu, Xiaoyin, Jiang, Nan, Cai, Shouliang, Jin, Feng, Yeung, Sai-Ching J., Lee, Mong-Hong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562308/
https://ncbi.nlm.nih.gov/pubmed/23187808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22887
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