COP1 enhances ubiquitin-mediated degradation of p27(Kip1) to promote cancer cell growth

p27 is a critical CDK inhibitor involved in cell cycle regulation, and its stability is critical for cell proliferation. Constitutive photomorphogenic 1 (COP1) is a RING-containing E3 ubiquitin ligase involved in regulating important target proteins for cell growth, but its biological activity in ce...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Choi, Hyun Ho, Phan, Liem, Chou, Ping-Chieh, Su, Chun-Hui, Yeung, Sai-Ching J., Chen, Jiun-Sheng, Lee, Mong-Hong
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637316/
https://ncbi.nlm.nih.gov/pubmed/26254224
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