CDK inhibitor p57(Kip2) is downregulated by Akt during HER2-mediated tumorigenicity

HER2/neu oncogene is frequently deregulated in cancers, and the (PI3K)-Akt signaling is one of the major pathways in mediating HER2/neu oncogenic signal. p57(Kip2), an inhibitor of cyclin-depependent kinases, is pivotal in regulating cell cycle progression, but its upstream regulators remain unclear...

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Detalhes bibliográficos
Main Authors: Zhao, Ruiying, Yang, Heng-Yin, Shin, Jihyun, Phan, Liem, Fang, Lekun, Che, Ting-Fang, Su, Chun-Hui, Yeung, Sai-Ching J., Lee, Mong-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637352/
https://ncbi.nlm.nih.gov/pubmed/23421998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23883
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