Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity

Cullin RING ligases (CRLs) are the largest family of cellular E3 ubiquitin ligases and mediate polyubiquitination of a number of cellular substrates. CRLs are activated via the covalent modification of the cullin protein with the ubiquitin-like protein Nedd8. This results in a conformational change...

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Bibliographic Details
Main Authors: Choo, Yin Yin, Boh, Boon Kim, Lou, Jessica Jie Wei, Eng, Jolane, Leck, Yee Chin, Anders, Benjamin, Smith, Peter G., Hagen, Thilo
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237615/
https://ncbi.nlm.nih.gov/pubmed/22013077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-03-0251
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