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Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity
Cullin RING ligases (CRLs) are the largest family of cellular E3 ubiquitin ligases and mediate polyubiquitination of a number of cellular substrates. CRLs are activated via the covalent modification of the cullin protein with the ubiquitin-like protein Nedd8. This results in a conformational change...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3237615/ https://ncbi.nlm.nih.gov/pubmed/22013077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-03-0251 |
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