Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

BACKGROUND: Aurora B kinase is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers and thus may be an important molecular target for chemotherapy. AZD1152 is the prodrug for AZD1152-HQPA, which is a selective inhibitor of Aurora B kinas...

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Detalhes bibliográficos
Main Authors: Gully, Christopher P, Zhang, Fanmao, Chen, Jian, Yeung, James A, Velazquez-Torres, Guermarie, Wang, Edward, Yeung, Sai-Ching Jim, Lee, Mong-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839967/
https://ncbi.nlm.nih.gov/pubmed/20175926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-42
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