Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

The overexpression of Aurora kinases in multiple tumors makes these kinases appealing targets for the development of anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target Aurora kinases and induce a DFG conformation change at t...

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Detalhes bibliográficos
Main Authors: Wu, Jiun-Ming, Chen, Chiung-Tong, Coumar, Mohane Selvaraj, Lin, Wen-Hsin, Chen, Zi-Jie, Hsu, John T.-A., Peng, Yi-Hui, Shiao, Hui-Yi, Lin, Wen-Hsing, Chu, Chang-Ying, Wu, Jian-Sung, Lin, Chih-Tsung, Chen, Ching-Ping, Hsueh, Ching-Cheng, Chang, Kai-Yen, Kao, Li-Pin, Huang, Chi-Ying F., Chao, Yu-Sheng, Wu, Su-Ying, Hsieh, Hsing-Pang, Chi, Ya-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651446/
https://ncbi.nlm.nih.gov/pubmed/23610398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220523110
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