Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

The overexpression of Aurora kinases in multiple tumors makes these kinases appealing targets for the development of anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target Aurora kinases and induce a DFG conformation change at t...

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Bibliografiske detaljer
Main Authors: Wu, Jiun-Ming, Chen, Chiung-Tong, Coumar, Mohane Selvaraj, Lin, Wen-Hsin, Chen, Zi-Jie, Hsu, John T.-A., Peng, Yi-Hui, Shiao, Hui-Yi, Lin, Wen-Hsing, Chu, Chang-Ying, Wu, Jian-Sung, Lin, Chih-Tsung, Chen, Ching-Ping, Hsueh, Ching-Cheng, Chang, Kai-Yen, Kao, Li-Pin, Huang, Chi-Ying F., Chao, Yu-Sheng, Wu, Su-Ying, Hsieh, Hsing-Pang, Chi, Ya-Hui
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651446/
https://ncbi.nlm.nih.gov/pubmed/23610398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220523110
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