Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

The overexpression of Aurora kinases in multiple tumors makes these kinases appealing targets for the development of anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target Aurora kinases and induce a DFG conformation change at t...

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書誌詳細
主要な著者: Wu, Jiun-Ming, Chen, Chiung-Tong, Coumar, Mohane Selvaraj, Lin, Wen-Hsin, Chen, Zi-Jie, Hsu, John T.-A., Peng, Yi-Hui, Shiao, Hui-Yi, Lin, Wen-Hsing, Chu, Chang-Ying, Wu, Jian-Sung, Lin, Chih-Tsung, Chen, Ching-Ping, Hsueh, Ching-Cheng, Chang, Kai-Yen, Kao, Li-Pin, Huang, Chi-Ying F., Chao, Yu-Sheng, Wu, Su-Ying, Hsieh, Hsing-Pang, Chi, Ya-Hui
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2013
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651446/
https://ncbi.nlm.nih.gov/pubmed/23610398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220523110
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