Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

The overexpression of Aurora kinases in multiple tumors makes these kinases appealing targets for the development of anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target Aurora kinases and induce a DFG conformation change at t...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Wu, Jiun-Ming, Chen, Chiung-Tong, Coumar, Mohane Selvaraj, Lin, Wen-Hsin, Chen, Zi-Jie, Hsu, John T.-A., Peng, Yi-Hui, Shiao, Hui-Yi, Lin, Wen-Hsing, Chu, Chang-Ying, Wu, Jian-Sung, Lin, Chih-Tsung, Chen, Ching-Ping, Hsueh, Ching-Cheng, Chang, Kai-Yen, Kao, Li-Pin, Huang, Chi-Ying F., Chao, Yu-Sheng, Wu, Su-Ying, Hsieh, Hsing-Pang, Chi, Ya-Hui
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651446/
https://ncbi.nlm.nih.gov/pubmed/23610398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220523110
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items