BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

BACKGROUND: Over-expression of Aurora kinases promotes the tumorigenesis of cells. The aim of this study was to determine the preclinical profile of a novel pan-Aurora kinase inhibitor, BPR1K653, as a candidate for anti-cancer therapy. Since expression of the drug efflux pump, MDR1, reduces the effe...

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Main Authors: Cheung, Chun Hei Antonio, Lin, Wen-Hsing, Hsu, John Tsu-An, Hour, Tzyh-Chyuan, Yeh, Teng-Kuang, Ko, Shengkai, Lien, Tzu-Wen, Coumar, Mohane Selvaraj, Liu, Jin-Fen, Lai, Wen-Yang, Shiao, Hui-Yi, Lee, Tian-Ren, Hsieh, Hsing-Pang, Chang, Jang-Yang
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160846/
https://ncbi.nlm.nih.gov/pubmed/21887256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023485
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