Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

The overexpression of Aurora kinases in multiple tumors makes these kinases appealing targets for the development of anticancer therapies. This study identified two small molecules with a furanopyrimidine core, IBPR001 and IBPR002, that target Aurora kinases and induce a DFG conformation change at t...

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Autors principals: Wu, Jiun-Ming, Chen, Chiung-Tong, Coumar, Mohane Selvaraj, Lin, Wen-Hsin, Chen, Zi-Jie, Hsu, John T.-A., Peng, Yi-Hui, Shiao, Hui-Yi, Lin, Wen-Hsing, Chu, Chang-Ying, Wu, Jian-Sung, Lin, Chih-Tsung, Chen, Ching-Ping, Hsueh, Ching-Cheng, Chang, Kai-Yen, Kao, Li-Pin, Huang, Chi-Ying F., Chao, Yu-Sheng, Wu, Su-Ying, Hsieh, Hsing-Pang, Chi, Ya-Hui
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651446/
https://ncbi.nlm.nih.gov/pubmed/23610398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220523110
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