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Aurora A Regulates the Activity of HURP by Controlling the Accessibility of Its Microtubule-binding Domain
HURP is a spindle-associated protein that mediates Ran-GTP-dependent assembly of the bipolar spindle and promotes chromosome congression and interkinetochore tension during mitosis. We report here a biochemical mechanism of HURP regulation by Aurora A, a key mitotic kinase that controls the assembly...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2366856/ https://ncbi.nlm.nih.gov/pubmed/18321990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-10-1088 |
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