Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

O-GlcNAcylation is an essential post-translational modification that has been implicated in neurodevelopmental and neurodegenerative disorders. O-GlcNAcase (OGA), the sole enzyme catalyzing the removal of O-GlcNAc from proteins, has emerged as a potential drug target. OGA consists of an N-terminal O...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Muha, Villő, Authier, Florence, Szoke-Kovacs, Zsombor, Johnson, Sara, Gallagher, Jennifer, McNeilly, Alison, McCrimmon, Rory J., Teboul, Lydia, van Aalten, Daan M.F.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2021
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7988489/
https://ncbi.nlm.nih.gov/pubmed/33610549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100439
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