Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex

Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Here we present evidence that backtracking extends into the viral realm, where backtracking...

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Udgivet i:bioRxiv
Main Authors: Malone, Brandon, Chen, James, Wang, Qi, Llewellyn, Eliza, Choi, Young Joo, Olinares, Paul Dominic B., Cao, Xinyun, Hernandez, Carolina, Eng, Edward T., Chait, Brian T., Shaw, David E., Landick, Robert, Darst, Seth A., Campbell, Elizabeth A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987028/
https://ncbi.nlm.nih.gov/pubmed/33758867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.13.435256
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