Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome is replicated-transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp8(2)/nsp12) along with a cast of accessory factors. One of these factors is the nsp13 helicase. Both the holo-RdRp and nsp13 a...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Chen, James, Malone, Brandon, Llewellyn, Eliza, Grasso, Michael, Shelton, Patrick M. M., Olinares, Paul Dominic B., Maruthi, Kashyap, Eng, Ed, Vatandaslar, Hasan, Chait, Brian T., Kapoor, Tarun, Darst, Seth A., Campbell, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359531/
https://ncbi.nlm.nih.gov/pubmed/32676607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.08.194084
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