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Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

The increasing prevalence of metallo‐β‐lactamase (MBL)‐expressing bacteria presents a worrying trend in antibiotic resistance. MBLs rely on active site zinc ions for their hydrolytic activity and the pursuit of MBL‐inhibitors has therefore involved the investigation of zinc chelators. To ensure that...

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Bibliografische gegevens
Gepubliceerd in:Chemistry
Hoofdauteurs: van Haren, Matthijs J., Tehrani, Kamaleddin H. M. E., Kotsogianni, Ioli, Wade, Nicola, Brüchle, Nora C., Mashayekhi, Vida, Martin, Nathaniel I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986777/
https://ncbi.nlm.nih.gov/pubmed/33237604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202004694
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