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Cephalosporin Prodrug Inhibitors Overcome Metallo‐β‐Lactamase Driven Antibiotic Resistance

The increasing prevalence of metallo‐β‐lactamase (MBL)‐expressing bacteria presents a worrying trend in antibiotic resistance. MBLs rely on active site zinc ions for their hydrolytic activity and the pursuit of MBL‐inhibitors has therefore involved the investigation of zinc chelators. To ensure that...

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Dades bibliogràfiques
Publicat a:Chemistry
Autors principals: van Haren, Matthijs J., Tehrani, Kamaleddin H. M. E., Kotsogianni, Ioli, Wade, Nicola, Brüchle, Nora C., Mashayekhi, Vida, Martin, Nathaniel I.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986777/
https://ncbi.nlm.nih.gov/pubmed/33237604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202004694
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