Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn(2+)

Class B metallo-β-lactamases (MBLs) are Zn(2+)-dependent enzymes that catalyze the hydrolysis of β-lactam antibiotics to confer resistance in bacteria. Several problematic groups of MBLs belong to subclass B1, including the binuclear New Delhi MBL (NDM), Verona integrin-encoded MBL, and imipenemase-...

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Vydáno v:J Biol Chem
Hlavní autoři: Sychantha, David, Rotondo, Caitlyn M., Tehrani, Kamaleddin H.M.E., Martin, Nathaniel I., Wright, Gerard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319579/
https://ncbi.nlm.nih.gov/pubmed/34181945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100918
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