Probing the interaction of Aspergillomarasmine A (AMA) with metallo-β-lactamases NDM-1, VIM-2, and IMP-7

The metallo-β-lactamases (MBLs) are a growing threat to the continued efficacy of β-lactam antibiotics. Recently, aspergillomarasmine A (AMA) was identified as an MBL inhibitor, but the mode of inhibition was not fully characterized. Equilibrium dialysis and metal analysis studies revealed that 2 eq...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Bergstrom, Alexander, Katko, Andrew, Adkins, Zach, Hill, Jessica, Cheng, Zishou, Burnett, Mia, Yang, Hao, Aitha, Mahesh, Mehaffey, M. Rachel, Brodbelt, Jennifer S., Tehrani, Kamaleddin H. M. E., Martin, Nathaniel I., Bonomo, Robert A., Page, Richard C., Tierney, David L., Fast, Walter, Wright, Gerard D., Crowder, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807211/
https://ncbi.nlm.nih.gov/pubmed/29091730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00106
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