Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-β-lactamase VIM-2

[Image: see text] This study examines metal binding to metallo-β-lactamase VIM-2, demonstrating the first successful preparation of a Co(II)-substituted VIM-2 analogue. Spectroscopic studies of the half- and fully metal loaded enzymes show that both Zn(II) and Co(II) bind cooperatively, where the ma...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Aitha, Mahesh, Marts, Amy R., Bergstrom, Alex, Møller, Abraham Jon, Moritz, Lindsay, Turner, Lucien, Nix, Jay C., Bonomo, Robert A., Page, Richard C., Tierney, David L., Crowder, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245990/
https://ncbi.nlm.nih.gov/pubmed/25356958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500916y
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