Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition

Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems. At present there are no clinically approved MBL inhibitors, and in order to develop such agents it is essential to understand their inhi...

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Bibliografiska uppgifter
I publikationen:ChemMedChem
Huvudupphovsmän: Wade, Nicola, Tehrani, Kamaleddin H. M. E., Brüchle, Nora C., van Haren, Matthijs J., Mashayekhi, Vida, Martin, Nathaniel I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2021
Ämnen:
Full Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248298/
https://ncbi.nlm.nih.gov/pubmed/33534956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202100042
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