A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not reproducibly grow in xenografts without manipulation...

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Vydáno v:Front Immunol
Hlavní autoři: Patten, Piers E. M., Ferrer, Gerardo, Chen, Shih-Shih, Kolitz, Jonathan E., Rai, Kanti R., Allen, Steven L., Barrientos, Jacqueline C., Ioannou, Nikolaos, Ramsay, Alan G., Chiorazzi, Nicholas
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985329/
https://ncbi.nlm.nih.gov/pubmed/33767698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.627020
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