A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not reproducibly grow in xenografts without manipulation...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Patten, Piers E. M., Ferrer, Gerardo, Chen, Shih-Shih, Kolitz, Jonathan E., Rai, Kanti R., Allen, Steven L., Barrientos, Jacqueline C., Ioannou, Nikolaos, Ramsay, Alan G., Chiorazzi, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985329/
https://ncbi.nlm.nih.gov/pubmed/33767698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.627020
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