Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6–deficient process

Xenografting primary tumor cells allows modeling of the heterogeneous natures of malignant diseases and the influences of the tissue microenvironment. Here, we demonstrate that xenografting primary chronic lymphocytic leukemia (CLL) B lymphocytes with activated autologous T cells into alymphoid mice...

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Pubblicato in:JCI Insight
Autori principali: Patten, Piers E.M., Ferrer, Gerardo, Chen, Shih-Shih, Simone, Rita, Marsilio, Sonia, Yan, Xiao-Jie, Gitto, Zachary, Yuan, Chaohui, Kolitz, Jonathan E., Barrientos, Jacqueline, Allen, Steven L., Rai, Kanti R., MacCarthy, Thomas, Chu, Charles C., Chiorazzi, Nicholas
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855875/
https://ncbi.nlm.nih.gov/pubmed/27158669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86288
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