Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6–deficient process

Xenografting primary tumor cells allows modeling of the heterogeneous natures of malignant diseases and the influences of the tissue microenvironment. Here, we demonstrate that xenografting primary chronic lymphocytic leukemia (CLL) B lymphocytes with activated autologous T cells into alymphoid mice...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Patten, Piers E.M., Ferrer, Gerardo, Chen, Shih-Shih, Simone, Rita, Marsilio, Sonia, Yan, Xiao-Jie, Gitto, Zachary, Yuan, Chaohui, Kolitz, Jonathan E., Barrientos, Jacqueline, Allen, Steven L., Rai, Kanti R., MacCarthy, Thomas, Chu, Charles C., Chiorazzi, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855875/
https://ncbi.nlm.nih.gov/pubmed/27158669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86288
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