IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and activation-induced deaminase (AID) could influence this process. However, this possibility has been questioned in CLL because the number of circulating AID mRNA(+) cells is exceedingly low; synthesis of AID protein b...

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Autors principals: Patten, Piers E. M., Chu, Charles C., Albesiano, Emilia, Damle, Rajendra N., Yan, Xiao-Jie, Kim, Dorothy, Zhang, Lu, Magli, Amanda R., Barrientos, Jacqueline, Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti R., Roa, Sergio, Mongini, Patricia K., MacCarthy, Thomas, Scharff, Matthew D., Chiorazzi, Nicholas
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520620/
https://ncbi.nlm.nih.gov/pubmed/23071276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-449744
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