T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients

Although B-cell chronic lymphocytic leukemia (B-CLL) clones with unmutated IGHV genes (U-CLL) exhibit greater telomerase activity than those with mutated IGHV genes (M-CLL), the extent to which B-cell receptor (BCR) triggering contributes to telomerase up-regulation is not known. Therefore, we studi...

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Hlavní autoři: Damle, Rajendra N., Temburni, Sonal, Banapour, Taraneh, Paul, Santanu, Mongini, Patricia K. A., Allen, Steven L., Kolitz, Jonathan E., Rai, Kanti R., Chiorazzi, Nicholas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448257/
https://ncbi.nlm.nih.gov/pubmed/22875913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-409110
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