Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course

Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, targeted and deep DNA sequencing of IGHV-IGHD-IGHJ r...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Bagnara, Davide, Tang, Catherine, Brown, Jennifer R., Kasar, Siddha, Fernandes, Stacey, Colombo, Monica, Vergani, Stefano, Mazzarello, Andrea N., Ghiotto, Fabio, Bruno, Silvia, Morabito, Fortunato, Rai, Kanti R., Kolitz, Jonathan E., Barrientos, Jacqueline C., Allen, Steven L., Fais, Franco, Scharff, Matthew D., MacCarthy, Thomas, Chiorazzi, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186829/
https://ncbi.nlm.nih.gov/pubmed/34113563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.640731
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