Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course

Analyses of IGHV gene mutations in chronic lymphocytic leukemia (CLL) have had a major impact on the prognostication and treatment of this disease. A hallmark of IGHV-mutation status is that it very rarely changes clonally over time. Nevertheless, targeted and deep DNA sequencing of IGHV-IGHD-IGHJ r...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Bagnara, Davide, Tang, Catherine, Brown, Jennifer R., Kasar, Siddha, Fernandes, Stacey, Colombo, Monica, Vergani, Stefano, Mazzarello, Andrea N., Ghiotto, Fabio, Bruno, Silvia, Morabito, Fortunato, Rai, Kanti R., Kolitz, Jonathan E., Barrientos, Jacqueline C., Allen, Steven L., Fais, Franco, Scharff, Matthew D., MacCarthy, Thomas, Chiorazzi, Nicholas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186829/
https://ncbi.nlm.nih.gov/pubmed/34113563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.640731
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