The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia

The targeting of mutations by Activation-Induced Deaminase (AID) is a key step in generating antibody diversity at the Immunoglobulin (Ig) loci but is also implicated in B-cell malignancies such as chronic lymphocytic leukemia (CLL). AID has previously been shown to preferentially deaminate WRC (W =...

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Udgivet i:PLoS One
Main Authors: Yuan, Chaohui, Chu, Charles C., Yan, Xiao-Jie, Bagnara, Davide, Chiorazzi, Nicholas, MacCarthy, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268644/
https://ncbi.nlm.nih.gov/pubmed/28125682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167602
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