TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells

Clinical progression of B cell chronic lymphocytic leukemia (B-CLL) reflects the clone’s Ag receptor (BCR) and involves stroma-dependent B-CLL growth within lymphoid tissue. Uniformly elevated expression of TLR-9, occasional MYD88 mutations, and BCR specificity for DNA or Ags physically linked to DN...

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Bibliographic Details
Published in:J Immunol
Main Authors: Mongini, Patricia K. A., Gupta, Rashmi, Boyle, Erin, Nieto, Jennifer, Lee, Hyunjoo, Stein, Joanna, Bandovic, Jela, Stankovic, Tatjana, Barrientos, Jacqueline, Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti, Chu, Charles C., Chiorazzi, Nicholas
Format: Artigo
Language:Inglês
Published: AAI 2015
Subjects:
Clinical and Human Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505957/
https://ncbi.nlm.nih.gov/pubmed/26136429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403189
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