Quantitative targeted proteomic analysis of potential markers of tyrosine kinase inhibitor (TKI) sensitivity in EGFR mutated lung adenocarcinoma

Lung cancer causes the highest mortality among all cancers. Patients harboring kinase domain mutations in the epidermal growth factor receptor (EGFR) respond to EGFR tyrosine kinase inhibitors (TKIs), however, acquired resistance always develops. Moreover, 30–40% of patients with EGFR mutations exhi...

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Veröffentlicht in:J Proteomics
Hauptverfasser: Awasthi, Shivangi, Maity, Tapan, Oyler, Benjamin L., Qi, Yue, Zhang, Xu, Goodlett, David R., Guha, Udayan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984720/
https://ncbi.nlm.nih.gov/pubmed/29660496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2018.04.005
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