EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

BACKGROUND. Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor heterogeneity in EGFR mutations is one potential explanation for this phenomenon. METHODS. We performed direct sequencing to id...

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Detalhes bibliográficos
Main Authors: Chen, Zhi-Yong, Zhong, Wen-Zhao, Zhang, Xu-Chao, Su, Jian, Yang, Xue-Ning, Chen, Zhi-Hong, Yang, Jin-Ji, Zhou, Qing, Yan, Hong-Hong, An, She-Juan, Chen, Hua-Jun, Jiang, Ben-Yuan, Mok, Tony S., Wu, Yi-Long
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Lung Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399655/
https://ncbi.nlm.nih.gov/pubmed/22673630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0385
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