EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

BACKGROUND. Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor heterogeneity in EGFR mutations is one potential explanation for this phenomenon. METHODS. We performed direct sequencing to id...

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Autores principales: Chen, Zhi-Yong, Zhong, Wen-Zhao, Zhang, Xu-Chao, Su, Jian, Yang, Xue-Ning, Chen, Zhi-Hong, Yang, Jin-Ji, Zhou, Qing, Yan, Hong-Hong, An, She-Juan, Chen, Hua-Jun, Jiang, Ben-Yuan, Mok, Tony S., Wu, Yi-Long
Formato: Artigo
Lenguaje:Inglês
Publicado: AlphaMed Press 2012
Materias:
Lung Cancer
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399655/
https://ncbi.nlm.nih.gov/pubmed/22673630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0385
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