EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

BACKGROUND. Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor heterogeneity in EGFR mutations is one potential explanation for this phenomenon. METHODS. We performed direct sequencing to id...

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Hlavní autoři: Chen, Zhi-Yong, Zhong, Wen-Zhao, Zhang, Xu-Chao, Su, Jian, Yang, Xue-Ning, Chen, Zhi-Hong, Yang, Jin-Ji, Zhou, Qing, Yan, Hong-Hong, An, She-Juan, Chen, Hua-Jun, Jiang, Ben-Yuan, Mok, Tony S., Wu, Yi-Long
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2012
Témata:
Lung Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399655/
https://ncbi.nlm.nih.gov/pubmed/22673630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0385
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