Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells

Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells. We recently found that the transcriptional factor Krüppel-like factor 2 (KLF2) binds to the CpG sequences in the hTERT promoter and inhibits hTERT gen...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Mizuguchi, Mariko, Hara, Toshifumi, Yoshita-Takahashi, Manami, Kohda, Takashi, Tanaka, Yuetsu, Nakamura, Masataka
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980061/
https://ncbi.nlm.nih.gov/pubmed/33768169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100984
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