Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells from chronic and acute myeloid leukemias, chronic...

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Autores principales: Karam, Maroun, Thenoz, Morgan, Capraro, Valérie, Robin, Jean-Philippe, Pinatel, Christiane, Lancon, Agnès, Galia, Perrine, Sibon, David, Thomas, Xavier, Ducastelle-Lepretre, Sophie, Nicolini, Franck, El-Hamri, Mohamed, Chelghoun, Youcef, Wattel, Eric, Mortreux, Franck
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927101/
https://ncbi.nlm.nih.gov/pubmed/24563617
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