Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells from chronic and acute myeloid leukemias, chronic...

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Detalhes bibliográficos
Main Authors: Karam, Maroun, Thenoz, Morgan, Capraro, Valérie, Robin, Jean-Philippe, Pinatel, Christiane, Lancon, Agnès, Galia, Perrine, Sibon, David, Thomas, Xavier, Ducastelle-Lepretre, Sophie, Nicolini, Franck, El-Hamri, Mohamed, Chelghoun, Youcef, Wattel, Eric, Mortreux, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927101/
https://ncbi.nlm.nih.gov/pubmed/24563617
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