A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that restrict it to native conformers. Acting after endoplasmic reticulum (ER)-resident chaperones, ERp44 retrieves its clients from downstream compartments...

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Bibliografske podrobnosti
izdano v:iScience
Main Authors: Tempio, Tiziana, Orsi, Andrea, Sicari, Daria, Valetti, Caterina, Yoboue, Edgar Djaha, Anelli, Tiziana, Sitia, Roberto
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973864/
https://ncbi.nlm.nih.gov/pubmed/33763635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102244
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