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Progressive quality control of secretory proteins in the early secretory compartment by ERp44
ERp44 is a pH-regulated chaperone of the secretory pathway. In the acidic milieu of the Golgi, its C-terminal tail changes conformation, simultaneously exposing the substrate-binding site for cargo capture and the RDEL motif for ER retrieval via interactions with cognate receptors. Protonation of cy...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4251952/ https://ncbi.nlm.nih.gov/pubmed/25097228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.153239 |
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