A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that restrict it to native conformers. Acting after endoplasmic reticulum (ER)-resident chaperones, ERp44 retrieves its clients from downstream compartments...

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Publicat a:iScience
Autors principals: Tempio, Tiziana, Orsi, Andrea, Sicari, Daria, Valetti, Caterina, Yoboue, Edgar Djaha, Anelli, Tiziana, Sitia, Roberto
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973864/
https://ncbi.nlm.nih.gov/pubmed/33763635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102244
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