A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that restrict it to native conformers. Acting after endoplasmic reticulum (ER)-resident chaperones, ERp44 retrieves its clients from downstream compartments...

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Veröffentlicht in:iScience
Hauptverfasser: Tempio, Tiziana, Orsi, Andrea, Sicari, Daria, Valetti, Caterina, Yoboue, Edgar Djaha, Anelli, Tiziana, Sitia, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7973864/
https://ncbi.nlm.nih.gov/pubmed/33763635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102244
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