Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis

The biogenesis of secretory IgM occurs stepwise under stringent quality control, formation of μ(2)L(2) preceding polymerization. How is efficiency of IgM secretion coupled to fidelity? We show here that ERp44, a soluble protein involved in thiol-mediated retention, interacts with ERGIC-53. Binding t...

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Bibliographische Detailangaben
Hauptverfasser: Anelli, Tiziana, Ceppi, Stefania, Bergamelli, Leda, Cortini, Margherita, Masciarelli, Silvia, Valetti, Caterina, Sitia, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230840/
https://ncbi.nlm.nih.gov/pubmed/17805346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601844
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