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Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis
The biogenesis of secretory IgM occurs stepwise under stringent quality control, formation of μ(2)L(2) preceding polymerization. How is efficiency of IgM secretion coupled to fidelity? We show here that ERp44, a soluble protein involved in thiol-mediated retention, interacts with ERGIC-53. Binding t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2230840/ https://ncbi.nlm.nih.gov/pubmed/17805346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601844 |
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