Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Zinc ions (Zn(2+)) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood. Here, we show that Zn(2+) binds with high affinity to the pH-sensitive chaperone ERp44, modulating its localization and ability to retrieve clie...

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Pubblicato in:Nat Commun
Autori principali: Watanabe, Satoshi, Amagai, Yuta, Sannino, Sara, Tempio, Tiziana, Anelli, Tiziana, Harayama, Manami, Masui, Shoji, Sorrentino, Ilaria, Yamada, Momo, Sitia, Roberto, Inaba, Kenji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363758/
https://ncbi.nlm.nih.gov/pubmed/30723194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08429-1
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