Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere

The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C(2)-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-THF of darunavir on either side of the Phe-Phe is...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Rusere, Linah N., Lockbaum, Gordon J., Henes, Mina, Lee, Sook-Kyung, Spielvogel, Ean, Rao, Desaboini Nageswara, Kosovrasti, Klajdi, Nalivaika, Ellen A., Swanstrom, Ronald, Yilmaz, Nese Kurt, Schiffer, Celia A., Ali, Akbar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971191/
https://ncbi.nlm.nih.gov/pubmed/32672965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00529
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