In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)

Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP map to either a short junctional sequence or the central (NP...

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Udgivet i:Sci Rep
Main Authors: Livingstone, Merricka C., Bitzer, Alexis A., Giri, Alish, Luo, Kun, Sankhala, Rajeshwer S., Choe, Misook, Zou, Xiaoyan, Dennison, S. Moses, Li, Yuanzhang, Washington, William, Ngauy, Viseth, Tomaras, Georgia D., Joyce, M. Gordon, Batchelor, Adrian H., Dutta, Sheetij
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970865/
https://ncbi.nlm.nih.gov/pubmed/33674699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84622-x
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