Optimization of a Plasmodium falciparum circumsporozoite protein repeat vaccine using the tobacco mosaic virus platform

Plasmodium falciparum vaccine RTS,S/AS01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP). RTS,S-induced NPNA-specific antibody titer and avidity have been associated with high-level protection in naïve subjects, but efficacy and longevity in target p...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Langowski, Mark D., Khan, Farhat A., Bitzer, Alexis A., Genito, Christopher J., Schrader, Andrew J., Martin, Monica L., Soto, Kimberly, Zou, Xiaoyan, Hadiwidjojo, Sri, Beck, Zoltan, Matyas, Gary R., Livingstone, Merricka C., Batchelor, Adrian H., Dutta, Sheetij
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022184/
https://ncbi.nlm.nih.gov/pubmed/31988134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911792117
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