Optimization of a Plasmodium falciparum circumsporozoite protein repeat vaccine using the tobacco mosaic virus platform

Plasmodium falciparum vaccine RTS,S/AS01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP). RTS,S-induced NPNA-specific antibody titer and avidity have been associated with high-level protection in naïve subjects, but efficacy and longevity in target p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Langowski, Mark D., Khan, Farhat A., Bitzer, Alexis A., Genito, Christopher J., Schrader, Andrew J., Martin, Monica L., Soto, Kimberly, Zou, Xiaoyan, Hadiwidjojo, Sri, Beck, Zoltan, Matyas, Gary R., Livingstone, Merricka C., Batchelor, Adrian H., Dutta, Sheetij
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022184/
https://ncbi.nlm.nih.gov/pubmed/31988134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911792117
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