Optimization of a Plasmodium falciparum circumsporozoite protein repeat vaccine using the tobacco mosaic virus platform

Plasmodium falciparum vaccine RTS,S/AS01 is based on the major NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP). RTS,S-induced NPNA-specific antibody titer and avidity have been associated with high-level protection in naïve subjects, but efficacy and longevity in target p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Langowski, Mark D., Khan, Farhat A., Bitzer, Alexis A., Genito, Christopher J., Schrader, Andrew J., Martin, Monica L., Soto, Kimberly, Zou, Xiaoyan, Hadiwidjojo, Sri, Beck, Zoltan, Matyas, Gary R., Livingstone, Merricka C., Batchelor, Adrian H., Dutta, Sheetij
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022184/
https://ncbi.nlm.nih.gov/pubmed/31988134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911792117
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