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Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

BACKGROUND: Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. We assessed triptolide as a potential therapy. METHODS: SH-SY5Y and IMR-32 neuroblastoma cell lines were treated with triptolide. Viability, intracellular calcium, caspase activation, protei...

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書目詳細資料
發表在:	Am J Surg
Main Authors:	Krosch, Tara C. K., Sangwan, Veena, Banerjee, Sulagna, Mujumdar, Nameeta, Dudeja, Vikas, Saluja, Ashok K., Vickers, Selwyn M.
格式:	Artigo
語言:	Inglês
出版:	2013
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7970732/ https://ncbi.nlm.nih.gov/pubmed/23428154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2013.01.008
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Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

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