Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

BACKGROUND: Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. We assessed triptolide as a potential therapy. METHODS: SH-SY5Y and IMR-32 neuroblastoma cell lines were treated with triptolide. Viability, intracellular calcium, caspase activation, protei...

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Detalhes bibliográficos
Publicado no:Am J Surg
Main Authors: Krosch, Tara C. K., Sangwan, Veena, Banerjee, Sulagna, Mujumdar, Nameeta, Dudeja, Vikas, Saluja, Ashok K., Vickers, Selwyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970732/
https://ncbi.nlm.nih.gov/pubmed/23428154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2013.01.008
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