MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization.

BACKGROUND:MUC1 is a type I transmembrane glycoprotein aberrantly overexpressed in various cancer cells including pancreatic cancer. The cytosolic end of MUC1 (MUC1-c) is extensively involved in a number of signaling pathways. MUC1-c is reported to inhibit apoptosis in a number of cancer cells, but...

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Hlavní autoři: Sulagna Banerjee, Nameeta Mujumdar, Vikas Dudeja, Tiffany Mackenzie, Tara K Krosch, Veena Sangwan, Selwyn M Vickers, Ashok K Saluja
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2012-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3418232?pdf=render
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