Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms are poorly understood. We report that bone-borne TGF-β induces the acetylation of transcription factor KLF5 in PCa bone metastases, and acetylated KLF5 (Ac-KLF5) causes o...

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Publicado no:Nat Commun
Main Authors: Zhang, Baotong, Li, Yixiang, Wu, Qiao, Xie, Lin, Barwick, Benjamin, Fu, Changying, Li, Xin, Wu, Daqing, Xia, Siyuan, Chen, Jing, Qian, Wei Ping, Yang, Lily, Osunkoya, Adeboye O., Boise, Lawrence, Vertino, Paula M., Zhao, Yichao, Li, Menglin, Chen, Hsiao-Rong, Kowalski, Jeanne, Kucuk, Omer, Zhou, Wei, Dong, Jin-Tang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969754/
https://ncbi.nlm.nih.gov/pubmed/33731701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21976-w
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