Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms are poorly understood. We report that bone-borne TGF-β induces the acetylation of transcription factor KLF5 in PCa bone metastases, and acetylated KLF5 (Ac-KLF5) causes o...

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Publicat a:Nat Commun
Autors principals: Zhang, Baotong, Li, Yixiang, Wu, Qiao, Xie, Lin, Barwick, Benjamin, Fu, Changying, Li, Xin, Wu, Daqing, Xia, Siyuan, Chen, Jing, Qian, Wei Ping, Yang, Lily, Osunkoya, Adeboye O., Boise, Lawrence, Vertino, Paula M., Zhao, Yichao, Li, Menglin, Chen, Hsiao-Rong, Kowalski, Jeanne, Kucuk, Omer, Zhou, Wei, Dong, Jin-Tang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969754/
https://ncbi.nlm.nih.gov/pubmed/33731701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21976-w
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