Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as transcriptomic profiling, to investigate how variabili...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Dziedzicka, Dominika, Tewary, Mukul, Keller, Alexander, Tilleman, Laurentijn, Prochazka, Laura, Östblom, Joel, Couvreu De Deckersberg, Edouard, Markouli, Christina, Franck, Silvie, Van Nieuwerburgh, Filip, Spits, Claudia, Zandstra, Peter W., Sermon, Karen, Geens, Mieke
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969605/
https://ncbi.nlm.nih.gov/pubmed/33731744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85447-4
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